Potential Negative Effects of Antimicrobial Allergy Labelling on Patient Care: A Systematic Review

Potential Negative Effects of Antimicrobial Allergy Labelling on Patient Care: A Systematic Review

Julie Hui-Chih Wu, Bradley J Langford, Kevin L Schwartz, Rosemary Zvonar, Sumit Raybardhan, Valerie Leung, Gary Garber



Antimicrobial allergy labels, either self-reported or placed in a patient’s medical record, are common, but in many cases they are not associated with a true immunoglobulin E–mediated allergic response.


To assess the impact of antimicrobial allergy labels on antimicrobial prescribing, resource utilization, and clinical outcomes.

Data Sources

The MEDLINE, Embase, CINAHL, and Scopus electronic databases were searched for the period 1990 to January 2016.

Study Selection

Controlled studies with the objective of assessing antimicrobial prescribing, resource utilization, and/or clinical outcomes associated with antimicrobial allergy labels were included.


The search identified 560 unique citations, of which 7 articles met the inclusion criteria. One additional article identified by an expert in the field was also included. Four of the identified papers were limited to penicillin or other β-lactam allergies. Six studies noted differences in antibiotic selection between patients with allergy labels and those without such labels. Broader-spectrum or second-line agents (e.g., vancomycin, clindamycin, and fluoroquinolones) were more commonly prescribed for patients with penicillin allergy labels. Antibiotic therapy costs were significantly higher for patients with allergy labels than for those without. The impact of allergy labels on clinical outcomes was mixed. One study indicated a longer length of hospital stay, 2 studies reported higher readmission rates, and 1 study reported a higher rate of antibiotic-resistant organisms for patients with allergy labels.


Most of the available literature is limited to penicillin or β-lactam allergy. The growing body of knowledge supports the concept that β-lactam allergy labels are not benign and that labelling in the absence of a true allergy has a negative effect on patient care. Allergy labelling appears to be associated with suboptimal antibiotic selection, greater treatment costs, prolonged length of stay, greater readmission rates, and higher prevalence of antibiotic-resistant organisms. There is an opportunity for antimicrobial stewardship programs to implement systematic allergy verification to optimize antimicrobial therapy and improve patient care.

KEYWORDS: antimicrobial allergy labels, antibiotic allergy, antimicrobial stewardship, antibiotic stewardship



Les mentions d’allergies aux antimicrobiens, soit autodéclarées soit consignées dans un dossier médical, sont fréquentes, mais dans bien des cas elles ne signalent pas une véritable réaction allergique à médiation par l’immunoglobuline E.


Évaluer l’effet des mentions d’allergie aux antimicrobiens sur les habitudes de prescription d’antimicrobiens, l’utilisation des ressources et les résultats cliniques.

Sources des données

Les bases de données numériques MEDLINE, Embase, CINAHL et Scopus ont été interrogées pour la période allant de 1990 à janvier 2016.

Sélection des études

Les essais cliniques comparatifs dont l’objectif était d’évaluer les habitudes de prescription d’antimicrobiens, l’utilisation des ressources ou les résultats cliniques associés aux mentions d’allergie aux antimicrobiens ont été inclus.


La recherche a permis de trouver 560 citations distinctes et ainsi de repérer sept articles qui répondaient aux critères d’inclusion. Un article supplémentaire signalé par un expert du domaine a été inclus à l’analyse. Quatre de ces articles se limitaient aux allergies à la pénicilline ou à d’autres β-lactamines. Six études ont noté des différences dans le choix des antibiotiques entre les patients ayant une mention d’allergie à leur dossier et ceux n’en ayant pas. Des antibiotiques à plus large spectre ou des médicaments de deuxième intention (comme la vancomycine, la clindamycine et les fluoroquinolones) étaient plus souvent prescrits pour les patients ayant une mention d’allergie à la pénicilline. Les coûts des antibiothérapies étaient significativement plus élevés pour les patients ayant une mention d’allergie que pour ceux n’en ayant pas à leur dossier. L’effet des mentions d’allergie sur les résultats cliniques était inégal. Une étude indiquait un séjour plus long à l’hôpital, deux études indiquaient des taux de réadmission plus élevés et une étude indiquait un taux plus élevé d’organismes résistants aux antibiotiques pour les patients ayant une mention d’allergie comparativement à ceux n’en ayant pas.


La majeure partie des articles disponibles se limitent aux allergies à la pénicilline ou à d’autres β-lactamines. De plus en plus, le savoir vient appuyer le concept voulant que les mentions d’allergies aux β-lactamines ne soient pas bénignes et que leur emploi en l’absence d’une allergie réelle ait un effet négatif sur les soins aux patients. Les mentions d’allergie semblent être associées à un choix sous-optimal d’antibiotiques, des coûts de traitement plus élevés, des séjours plus longs, des taux de réadmission plus élevés et une plus grande prévalence d’organismes résistants aux antibiotiques. Or, les programmes de gérance des antimicrobiens pourraient permettre de mettre en œuvre des procédures de vérification systématique des allergies afin d’optimiser l’antibiothérapie et d’améliorer les soins aux patients.

MOTS CLÉS: mentions d’allergie aux antimicrobiens, allergie aux antibiotiques, gérance des antimicrobiens, gérance des antibiotiques


Antibiotic resistance is a growing public health problem, with substantial burden throughout the health care system.1 It is generally recognized that inappropriate antibiotic prescribing and unnecessary use of broad-spectrum antibiotics contribute to antibiotic resistance. Both inappropriate antibiotic prescribing and antibiotic resistance are associated with increased morbidity and mortality.2,3

Although many patients report or have a medical record of antimicrobial allergies, referred to as “allergy labels”, not all of these allergy labels are accurate. Inaccurate antimicrobial allergy labelling contributes to inappropriate antibiotic selection through prescribers’ avoidance of first-line or narrow-spectrum antibiotics. This can result in the use of broader-spectrum antibiotics, suboptimal therapy, and increased risks of antibiotic resistance and adverse events, as well as increased costs.4 Reporting of antibiotic allergies is common. Trubiano and others5 stated that 25% of patients admitted to hospital had documentation of an antimicrobial allergy, with 70% of these allergies involving β-lactams. Although the prevalence of reported β-lactam allergies is high, confirmed (true) allergic reactions are less common. For example, Park and others6 showed that 96% of patients with a self-reported penicillin allergy did not have a true immunoglobulin E (IgE)-mediated allergy based on penicillin skin testing.6 Reporting rates of true allergies to classes of antimicrobials other than β-lactams are scarce.

Antimicrobial stewardship programs aim to optimize antimicrobial use, thereby improving patient outcomes, minimizing adverse effects, and reducing Clostridium difficile infections and the development of antimicrobial resistance.7 A greater understanding of the impact of antimicrobial allergy labels can provide an impetus for improved allergy verification strategies, aimed at optimizing selection of antimicrobial therapy and patient outcomes.

This systematic review was performed to answer the following 3 separate but related questions: What is the impact of antimicrobial allergy labels on antimicrobial prescribing (e.g., choice and duration of therapy)? Do antimicrobial allergy labels increase health care costs and resource utilization? What is the effect of antimicrobial allergy labels on clinical outcomes (e.g., hospital length of stay, readmission rates, and mortality)?


Searches for English-language articles published since 1990 were conducted in 4 databases (initially performed in MEDLINE and adapted into Embase, CINAHL, and Scopus) on January 18 and 21, 2016, by Public Health Ontario Library Services. The search concepts were “antimicrobial/antibiotic allergy label”, “antimicrobial/antibiotic”, and “patient/prescribing/utilization outcomes”. Both primary literature and review articles were included. The full search strategy is available in Appendix 1 (see https://www.cjhp-online.ca/index.php/cjhp/issue/view/125/showToc).

English-language articles retrieved by the searches were assessed for eligibility. To ensure that the review would be comprehensive, there were no restrictions on study design, population, antimicrobial allergy, health care setting, or outcomes. Articles were included if the objective of the research was to assess the impact of antimicrobial allergy labels, relative to a control group, on antimicrobial prescribing, resource utilization, and/or clinical outcomes. Case reports and studies involving non-antimicrobial allergies, the efficacy or safety of antimicrobial allergy testing, or drug intolerance were excluded. Title and abstract screening, as well as full-text screening, was performed individually in duplicate by 2 reviewers (J.H.C.W. and B.J.L.). Data for overall results (e.g., allergy label versus control) were extracted by one of these reviewers (J.H.C.W.), with extraction verified by the second reviewer (B.J.L.) for 20% of the articles. Any disagreements regarding inclusion or data abstraction were resolved by consensus. Subgroup analyses, such as female versus male, were excluded. Results that did not reach statistical significance were recorded as not different from the control group. Because the inclusion criteria were broad (with inclusion of studies examining any allergy label, population, age, setting, and outcome), a descriptive analysis was performed.


The search identified 560 unique citations, with 7 articles meeting the inclusion criteria. During the review process, 1 additional article was identified by an expert in the field and was included. No reviews were found. Therefore, a total of 8 articles were included in the analysis5,814 (Table 1).

Table 1 Summary of Studies Included in a Systematic Review of Antimicrobial Allergy Labelling


The publication year of the included articles ranged from 2000 to 2015. Four studies were conducted in the United States,810,14 2 in Australia,5,12 1 in Canada,13 and 1 in Israel.11 The studies varied with respect to population (e.g., patients with penicillin allergy or any antimicrobial allergy), comparator (e.g., matched controls, patients with no antimicrobial allergies), methodology, and outcomes assessed (see Table 1).

Two studies included only adult patients.8,14 Seven of the 8 studies focused on inpatients,5,8,1014 and the other study focused on outpatients.9 Four studies included patients labelled as having any type of antimicrobial allergy,5,8,12,14 3 studies focused on penicillin allergy,10,11,13 and 1 study included any β-lactam allergy.9 None of the studies reported the source of the allergy labels (e.g., patient self-report or documented reaction). Three of the 4 studies that were not limited to β-lactam allergies reported the prevalence of allergies to specific agents. Although allergies to penicillin and other β-lactams were most common, 11%–21% of reported allergies were to sulfonamides, 7% to vancomycin, and less than 6% to each of fluoroquinolones, metronidazole, macrolides, and doxycycline.5,12,14

Prescribing Outcomes

Prescribing outcomes were reported in all 8 of the included studies. The prescribing outcomes considered were antimicrobial selection, duration of therapy, and appropriateness. Seven of the 8 studies reported differences in antibiotic selection between patients with allergy labels and controls.5,914

Alternative antibiotics were significantly more likely to be used for patients with penicillin allergy labels than for those without (38% versus 15%, p < 0.0001), as well as for those with cephalosporin allergy labels than for those without (55% versus 27%, p = 0.0007).14 Patients with allergy labels were more likely to receive cephalosporins9,11,12 (including first- to fourth-generation cephalosporins, p < 0.00111,12) and non-β-lactam antibiotics.5,9,10,1214 Non-β-lactam antibiotics that were used more frequently for patients with an allergy label were clindamycin,10,14 vancomycin,10,11,13,14 macrolides,9,11 and fluoro-quinolones.1014 In contrast, significantly lower cephalosporin use was noted for patients reported to have penicillin allergy relative to controls in 2 studies (24% versus 43%, p = 0.055; 32% versus 50%, p < 0.000110), including first-generation cephalosporins (16% versus 33%, p < 0.0001) and third-generation or higher cephalosporins (20% versus 23%, p < 0.0001).10

In the study by Sade and others,11 a penicillin allergy label had no effect on the number of antibiotics prescribed, the number of antibiotics given parenterally, the duration of antibiotic therapy, or the frequency of administration. However, other studies identified significantly higher numbers of antibiotics employed (odds ratio [OR] 1.51, 95% confidence interval [CI] 1.33–1.708) among patients with allergy labels than among those without allergy (average of 3 versus 2 antibiotics per admission, p = 0.01).12

Trubiano and others12 reported that the presence of an allergy label was associated with a longer course of antibiotic therapy in hospitalized cancer patients after multivariable adjustment (p = 0.03). In another study, Trubiano and others5 observed a significantly longer antibiotic duration for patients admitted to a tertiary care hospital (median duration 6 versus 4 days, p = 0.018) and a significantly higher use of IV relative to oral antibiotics in patients with an allergy label (60% versus 46%, p = 0.0001).

Trubiano and others5 found no statistically significant difference between patients with allergy labels and those without in terms of appropriate antibiotic selection (using criteria from the National Antimicrobial Prescribing Survey of Australia; 29% versus 23%, p = 0.22) or the use of restricted antimicrobials (25% versus 24%, p = 0.44). However, in a different study, Trubiano and others12 observed significantly less concordance with prescribing guidelines for patients with an antimicrobial allergy label (47% versus 91%, p < 0.001); Lutomski and others14 also observed 30% deviation from standard of care (no statistical analysis reported).

Utilization Outcomes

Four studies reported on costs as a utilization outcome. Three of these reported antibiotic costs9,11,13 and 1 translated hospital length of stay and total hospital use into financial costs.10

MacLaughlin and others9 examined patients for whom antibiotics were prescribed in a family medicine clinic and observed a significantly higher mean antibiotic cost for individuals with a β-lactam allergy label than for those without (65% higher). Similarly, if a penicillin allergy label was present, there were significantly higher costs for antibiotic therapy during hospital admission (56% higher) and after discharge (38% higher).11 A Canadian study conducted in 2009 by Picard and others13 found that the use of alternative antibiotics in place of standard-of-care β-lactam regimens carried an additional cost of Can$326.50 per patient. Finally, the observed average increase in length of stay—0.59 days per penicillin-allergic patient—in a US hospital translated to an estimated total of US$64 626 630 over the study period (2010–2012).10 This increased expenditure was reported to be approximately 9.5 times greater than the cost of conducting penicillin allergy testing in those patients.10

Clinical Outcomes

Clinical outcomes, reported by 4 studies, included length of stay,8,1012 readmission,8,12 and death.8,11,12 Overall, the effects of allergy labels on the various clinical outcomes were mixed.

Of the 4 studies assessing hospital length of stay, 2 studies indicated an increase among those with allergy labels (by 0.59 days [95% CI 0.47–0.71]10 and by 1.16 days8), whereas the other 2 studies reported no significant difference.11,12 Two studies reported admission and readmission rates.8,12 One of these studies reported a significantly higher ICU admission rate (adjusted OR 1.42, 95% CI 1.21–1.67),8 and the other reported a higher readmission rate due to diagnosis of an infectious disease requiring antimicrobial therapy in patients labelled as having an antimicrobial allergy (adjusted OR 3.27, 95% CI 1.55–6.88).12 However, presence of an allergy label was not significantly associated with an increased overall risk of readmission (adjusted OR 1.99, 95% CI 0.95–4.15)12 or the readmission rate within 4 weeks of discharge (adjusted OR 0.71, 95% CI 0.63–0.80).8 Mixed results were also observed for the mortality outcome. Two studies found no difference in 30- and 60-day mortality12 or in-hospital mortality,11 whereas Charneski and others8 indicated that patients with an antimicrobial allergy label had a significantly higher risk of in-hospital death (adjusted OR 1.56, 95% CI 1.20–2.04) relative to those with no reported allergy. The presence of a penicillin allergy label was associated with significantly higher prevalences of infection with C. difficile (OR 1.23, 95% CI 1.16–1.32), methicillin-resistant Staphylococcus aureus (OR 1.14, 95% CI 1.07–1.32), and vancomycin-resistant Enterococcus (OR 1.30, 95% CI 1.13–1.50).10


This systematic review assessed the potential negative impact of antimicrobial allergy labels on patient care. Although results varied, the studies included in this review found that reported antimicrobial allergies may be associated with worse clinical outcomes, including longer hospital stay,8,10 higher readmission rates,8,12 and higher mortality,8 with increased treatment costs relative to those without allergies.911,13 Given that antimicrobial allergy labels are common at the time of hospital admission, at a frequency ranging from 6%11 to as high as 25%,5 these negative clinical consequences have the potential to affect a large population.

In addition to their association with negative clinical outcomes, antimicrobial allergy labels may also lead to potentially unnecessary use of broad-spectrum antibiotics. β-Lactams are frequently considered as first-line agents for many infections, given their proven clinical efficacy, safety, tolerability, and low propensity for drug interactions.1517 Use of alternative agents (e.g., vancomycin for serious infections due to methicillin-susceptible S. aureus) can compromise clinical efficacy.18,19 Furthermore, alternative agents such as clindamycin and fluoroquinolones, which are frequently used for patients with allergy to penicillin or cephalosporin, have been associated with an increase in frequency of C. difficile infection.10,20,21 In addition, the use of broader-spectrum agents and a greater number of antibiotics for a longer treatment course increases costs and the risk of antimicrobial resistance.4,9

Many of the studies included in this review described differences in antibiotic selection between patients with and without allergy labels, but few commented on the appropriateness of the chosen therapy. This may be because appropriateness of therapy is more difficult to assess, despite it being a key component of antimicrobial stewardship. Notably, most of the studies involved hospital inpatients. As a result, less insight is available regarding the outcomes of allergy labels in community practice.

Accurately assessing reported allergies to provide the best antimicrobial therapy is an important antimicrobial stewardship initiative.7 Studies assessing allergy verification procedures have found that 84% to 99% of those with self-reported penicillin allergy are found to not have a true allergy and thus can be “de-labelled”.6,2227 Hence, it is important for clinicians to carefully evaluate allergy status before prescribing alternative antimicrobial therapy. Allergy labels should be assessed through a detailed clinical history characterizing the type and timing of previous reactions. Many β-lactams are well tolerated by patients with a history of penicillin allergy. For instance, cephalosporins can be safely administered to patients with a self-reported history of penicillin allergic reaction that occurred more than 10 years ago or if prior reactions did not include features of an IgE-mediated response, such as hives or anaphylaxis.28,29

Antibiotic allergy testing, in the form of a skin test, can be performed by trained health care professionals to help optimize antimicrobial use.30 A recent systematic review and meta-analysis of penicillin allergy verification interventions found that penicillin skin testing was the most commonly reported method of allergy verification.31 Allergy consultation before skin testing and pharmacy-driven interviews were other approaches.31 In particular, penicillin skin testing was found to be a safe and effective way to clarify allergy status in inpatient settings. In addition, ruling out penicillin allergy was shown to decrease health care costs and influence antibiotic selection, with increased prescribing of penicillin and cephalosporin and reduced prescribing of vancomycin and fluoroquinolone.31 Antimicrobial stewardship teams are encouraged to incorporate antibiotic allergy evaluation and testing into their programs.32

This review had some limitations. All relevant articles identified in the search were included in the analysis, because only a limited number of published studies were found. A quality assessment was not conducted, and therefore no exclusion criteria based on study quality were applied. There was substantial heterogeneity in the population and outcomes reported, which made it difficult to draw generalizable conclusions. All studies were retrospective in nature, introducing the possibility of unmeasured confounding factors. Many studies reported on differences in antibiotic selection between patients with and without antimicrobial allergies, but less frequently reported on appropriateness or clinical outcomes. As a result, definitive conclusions about the clinical impact of allergy labels will require further studies. Additionally, outcomes related to resolution of infection and adverse events were not reported in any of the studies, although these are important considerations when first-line antibiotics are not selected. Finally, most of the studies were hospital-based and focused on β-lactam antibiotics; therefore, this review may not be generalizable to non-β-lactam allergy labels or to patients in settings other than acute care hospitals.

The lack of review articles and the presence of only a handful of primary studies addressing the impact of antimicrobial allergy labels indicate a shortage of research in this area. However, it is evident from the data reported in this review and recent publications3336 that inaccurate antimicrobial allergy labels are associated with several important negative impacts on antimicrobial prescribing, patient care, and hospital resources. For example, one prospective study conducted in 3 academic hospitals in Toronto, and published after this review was completed, also identified an increased rate of adverse outcomes (particularly readmission to hospital and adverse drug reactions) among patients who received non-preferred therapy as a result of reported β-lactam allergy.36 A multicentre prospective evaluation of point-of-care β-lactam allergy skin testing by antimicrobial stewardship teams demonstrated the feasibility of systematic allergy verification as well as increased use of preferred β-lactam therapy in acute care hospitals without any increase in the risk of adverse drug reactions.30 A growing body of antimicrobial stewardship initiatives targeted toward patients with reported β-lactam allergies further emphasizes the benefit of allergy verification in this population.31,37 The impact of non-β-lactam allergy labels is not as well documented and may require further study.


This systematic review provides data to support antimicrobial stewardship programs in improving the appropriateness of antimicrobial therapy for patients labelled as having antimicrobial allergies. Policies and procedures to ensure systematic verification of allergies and selection of optimal antimicrobial therapy should be employed.


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5 Trubiano JA, Cairns KA, Evans JA, Ding A, Nguyen T, Dooley MJ, et al. The prevalence and impact of antimicrobial allergies and adverse drug reactions at an Australian tertiary centre. BMC Infect Dis. 2015;15:572.
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8 Charneski L, Deshpande G, Smith SW. Impact of an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. Pharmacotherapy. 2011;31(8):742–7.
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9 MacLaughlin EJ, Saseen JJ, Malone DC. Costs of β-lactam allergies: selection and costs of antibiotics for patients with a reported β-lactam allergy. Arch Fam Med. 2000;9(8):722–6.
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12 Trubiano JA, Leung VK, Chu MY, Worth LJ, Slavin MA, Thursky KA. The impact of antimicrobial allergy labels on antimicrobial usage in cancer patients. Antimicrob Resist Infect Control. 2015;4:23.
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16 Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJC, Baron EJ, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(2):133–64.

17 Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44 Suppl 2:S27–72.
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18 Bull AL, Worth LJ, Richards MJ. Impact of vancomycin surgical antibiotic prophylaxis on the development of methicillin-sensitive Staphylococcus aureus surgical site infections: report from Australian Surveillance Data (VICNISS). Ann Surg. 2012;256(6):1089–92.
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19 Kim SH, Kim KH, Kim HB, Kim NJ, Kim EC, Oh MD, et al. Outcome of vancomycin treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 2008;52(1):192–7.
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20 Deshpande A, Pasupuleti V, Thota P, Pant C, Rolston DDK, Sferra TJ, et al. Community-associated Clostridium difficile infection and antibiotics: a meta-analysis. J Antimicrob Chemother. 2013;68(9):1951–61.
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21 Wieczorkiewicz JT, Lopansri BK, Cheknis A, Osmolski JR, Hecht DW, Gerding DN, et al. Fluoroquinolone and macrolide exposure predict Clostridium difficile infection with the highly fluoroquinolone- and macrolide-resistant epidemic C. difficile strain BI/NAP1/027. Antimicrob Agents Chemother. 2015;60(1):418–23.
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22 Arroliga ME, Wagner W, Bobek MB, Hoffman-Hogg L, Gordon SM, Arroliga AC. A pilot study of penicillin skin testing in patients with a history of penicillin allergy admitted to a medical ICU. Chest. 2000;118(4):1106–8.
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23 Arroliga ME, Radojicic C, Gordon SM, Popovich MJ, Bashour CA, Melton AL, et al. A prospective observational study of the effect of penicillin skin testing on antibiotic use in the intensive care unit. Infect Control Hosp Epidemiol. 2003;24(5):347–50.
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24 Li JTC, Markus PJ, Osmon DR, Estes L, Gosselin VA, Hanssen AD. Reduction of vancomycin use in orthopedic patients with a history of antibiotic allergy. Mayo Clin Proc. 2000;75(9):902–6.
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25 Macy E. Elective penicillin skin testing and amoxicillin challenge: effect on outpatient antibiotic use, cost, and clinical outcomes. J Allergy Clin Immunol. 1998;102(2):281–5.
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26 Park MA, McClimon BJ, Ferguson B, Markus PJ, Odell L, Swanson A, et al. Collaboration between allergists and pharmacists increases β-lactam antibiotic prescriptions in patients with a history of penicillin allergy. Int Arch Allergy Immunol. 2011;154(1):57–62.

27 Nadarajah K, Green GR, Naglak M. Clinical outcomes of penicillin skin testing. Ann Allergy Asthma Immunol. 2005;95(6):541–5.

28 Daulat S, Solensky R, Earl HS, Casey W, Gruchalla RS. Safety of cephalosporin administration to patients with histories of penicillin allergy. J Allergy Clin Immunol. 2004;113(6):1220–2.
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29 Goodman EJ, Morgan MJ, Johnson PA, Nichols BA, Denk N, Gold BB. Cephalosporins can be given to penicillin-allergic patients who do not exhibit an anaphylactic response. J Clin Anesth. 2001;13(8):561–4.

30 Leis JA, Palmay L, Ho G, Raybardhan S, Gill S, Kan T, et al. Point-of-care β-lactam allergy skin testing by antimicrobial stewardship programs: a pragmatic multicenter prospective evaluation. Clin Infect Dis. 2017; 65(7): 1059–65.

31 Sacco KA, Bates A, Brigham TJ, Imam JS, Burton MC. Clinical outcomes following inpatient penicillin allergy testing: a systematic review and meta-analysis. Allergy. 2017;72(9):1288–96.
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32 Trubiano JA, Beekmann SE, Worth LJ, Polgreen PM, Thursky KA, Slavin MA, et al. Improving antimicrobial stewardship by antibiotic allergy delabeling: evaluation of knowledge, attitude, and practices throughout the emerging infections network. Open Forum Infect Dis. 2016;3(3):ofw153.
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33 Trubiano JA, Chen C, Cheng AC, Grayson ML, Slavin MA, Thursky KA; National Antimicrobial Prescribing Survey. Antimicrobial allergy ‘labels’ drive inappropriate antimicrobial prescribing: lessons for stewardship. J Antimicrob Chemother. 2016;71(6):1715–22.
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34 van Dijk SM, Gardarsdottir H, Wassenberg MWM, Oosterheert JJ, de Groot MCH, Rockmann H. The high impact of penicillin allergy registration in hospitalized patients. J Allergy Clin Immunol Pract. 2016;4(5):926–31.
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35 Su T, Broekhuizen BDL, Verheij TJM, Rockmann H. The impact of penicillin allergy labels on antibiotic and health care use in primary care: a retrospective cohort study. Clin Transl Allergy. 2017;7:18.
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36 MacFadden DR, LaDelfa A, Leen J, Gold WL, Daneman N, Weber E, et al. Impact of reported beta-lactam allergy on inpatient outcomes: a multicenter prospective cohort study. Clin Infect Dis. 2016;63(7):904–10.
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37 Vaisman A, McCready J, Hicks S, Powis J. Optimizing preoperative prophylaxis in patients with reported β-lactam allergy: a novel extension of antimicrobial stewardship. J Antimicrob Chemother. 2017;72(9):2657–60.
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Julie Hui-Chih Wu, MSc, is with Public Health Ontario, Toronto, Ontario.
Bradley J Langford, BScPhm, ACPR, PharmD, BCPS, is with Public Health Ontario, Toronto, Ontario.
Kevin L Schwartz, MD, MSc, FRCPC, is with Public Health Ontario and the Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario.
Rosemary Zvonar, BScPhm, ACPR, FCSHP, is with The Ottawa Hospital, Ottawa, Ontario.
Sumit Raybardhan, BScPhm, ACPR, MPH, is with North York General Hospital, Toronto, Ontario.
Valerie Leung, BScPhm, ACPR, MBA, is with Public Health Ontario, Toronto, Ontario.
Gary Garber, MD, FRCPC, FACP, FIDSA, CCPE, is with Public Health Ontario and the Department of Medicine, University of Toronto, Toronto, Ontario.

Competing interests: None declared. ( Return to Text )

Address correspondence to: Julie Hui-Chih Wu, Public Health Ontario, 480 University Avenue, Suite 300, Toronto ON M5G 1V2, E-mail: juliehc.wu@oahpp.ca

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Funding: None received. ( Return to Text )

Canadian Journal of Hospital Pharmacy, VOLUME 71, NUMBER 1, January-February 2018

ISSN 1920-2903 (Online)
Copyright © 2019 Canadian Society of Hospital Pharmacists