Olanzapine-Induced Diabetic Ketoacidosis Resulting in Prolongation of Hospital Stay: Clinical Outcome and Cost Issues
DOI:
https://doi.org/10.4212/cjhp.v60i3.174Abstract
INTRODUCTION
A typical antipsychotics are as effective as traditional antipsychotics in the treatment of chronic psychotic disorders and are associated with fewer extrapyramidal symptoms.1 Despite their lower propensity to induce extrapyramidal symptoms, these drugs are associated with other adverse effects, including anticholinergic effects, hypotension, sedation, sexual dysfunction, and weight gain.2 Endocrine disturbances such as hyperglycemia, new-onset type 2 diabetes mellitus, and ketoacidosis have been associated with atypical antipsychotics, including olanzapine.3 Diabetic ketoacidosis is a serious, potentially lifethreatening metabolic complication of diabetes mellitus.4 Numerous cases of this adverse effect have been reported during treatment with clozapine and olanzapine, but fewer case reports have been published for risperidone and quetiapine.3 We report a case of prolonged hospital stay resulting from olanzapineinduced diabetic ketoacidosis in a patient with no previous personal or family history of diabetes. This case illustrates the substantial morbidity associated with this adverse effect.
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