Leukocytoclastic Vasculitis Associated with Ciprofloxacin
DOI:
https://doi.org/10.4212/cjhp.v56i3.508Abstract
INTRODUCTION
Since its introduction on the Canadian market in 1989, ciprofloxacin has been generally well tolerated by patients. The most common side effects are gastrointestinal in nature (e.g., nausea, vomiting, and diarrhea), and some central nervous system effects, such as dizziness, have also been reported.1 These side effects are dose-dependent, occurring more frequently at higher doses. Despite its popularity and wide applicability, ciprofloxacin is rarely associated with hypersensitivity reactions (rash, pruritus, or photosensitivity occurs in less than 2% of cases), and severe anaphylactic or anaphylactoid reactions are even less frequent.2 This case report describes a patient who experienced a rare skin reaction with systemic involvement. Because there was a probable association with ciprofloxacin therapy, a brief review of the relevant literature for ciprofloxacin-induced vasculitis is also presented.
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